Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
Read More
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
Read More
Most Useful Reviews
9.5
Calcium normalised
My mum has taken calcium as prescribed by her doctor for over ten years, but it was never absorbed properly and her levels often dropped to a dangerous low, causing seizures. After trying this product, her calcium is now normal, which hasn't happened for a long time! I highly recommend this supplement, especially as it costs half the price of previous ones.
Read More
9.5
Weight loss success
My life has changed dramatically! I’ve lost a significant amount of weight, my high blood pressure has improved, and my cholesterol levels are down. I feel better than ever after taking this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
- All Researches
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
Read More
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
9
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Read More
9
We examined the effects of embelin, a compound derived from the dried berries of Embelia ribes, on cholesterol levels by focusing on its relationship with calcium in liver cells. Our analysis showed that embelin treatment aids in regulating cholesterol metabolism by influencing key proteins associated with cholesterol clearance.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
Read More
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Calcium normalised
My mum has taken calcium as prescribed by her doctor for over ten years, but it was never absorbed properly and her levels often dropped to a dangerous low, causing seizures. After trying this product, her calcium is now normal, which hasn't happened for a long time! I highly recommend this supplement, especially as it costs half the price of previous ones.
Read More
9.5
Weight loss success
My life has changed dramatically! I’ve lost a significant amount of weight, my high blood pressure has improved, and my cholesterol levels are down. I feel better than ever after taking this product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226
- Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. doi:10.1615/CritRevImmunol.2024052129
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
- Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
- Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. doi:10.1007/s11033-024-09408-6
- Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. doi:10.1080/10790268.2023.2257850
- Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. doi:10.1139/cjpp-2022-0359
- Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. doi:10.3390/nu15071645
- Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. doi:10.3389/fphar.2023.1135516
- Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. doi:10.3390/life13020581
- Chandran M, Rameshkumar KB, Jaleel A, Ayyappan JP. Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element-Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low-Density Lipoprotein Receptor Mediated Lipid Clearance on Hepatocytes. Chem Biol Drug Des. 2025;105:e70055. doi:10.1111/cbdd.70055
